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Pragmatic trials are trials designed to inform the real-world practice of clinical. They are often described as a focus on the practical aspects of designing a study which include recruitment and consent, adherence and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be valid and helps to reduce bias in the results. A high degree of heterogeneity, however could cause issues with the trial design.
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Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. Its software is accessible on mobile devices and in multiple languages. It has established itself as one of the top casino gaming platforms despite its relative infancy. Wolves is one of its latest releases that is a 5-reel slot machine with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. Usually, they are requested by practitioners and policymakers to help guide their decisions. They can also be a great way to identify the causality between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a practical trial that include recruitment, design and delivery of the intervention, and the follow-up.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.